P38 MAPK inhibition prevents polybrene-induced senescence of human mesenchymal stem cells during viral transduction
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چکیده
منابع مشابه
Polybrene Inhibits Human Mesenchymal Stem Cell Proliferation during Lentiviral Transduction
Human mesenchymal stem cells (hMSCs) can be engineered to express specific genes, either for their use in cell-based therapies or to track them in vivo over long periods of time. To obtain long-term expression of these genes, a lentivirus- or retrovirus-mediated cell transduction is often used. However, given that the efficiency with these viruses is typically low in primary cells, additives su...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0209606